Low ammonia diet for those with A1298, NOS, SUOX and CBS mutations

A low ammonia diet may be necessary when treating certain single nucleotide polymorphisms (SNPS). Ammonia is generated in the body when food is broken down in the intestines by bacteria that release ammonia into the body. Those particularly affected by ammonia are SUOX, NOS, A1298 and CBS. These snps affect certain metabolic pathways and can also reduce BH4 levels. It is also important to increase the levels of BH4, as well as reduce the levels of ammonia in the body.

Normally, BH4 is used to recycle and detoxify ammonia, but when it is lowered and there are normal or elevated levels of ammonia, these can cause a variety of health problems. These health problems can range from brain fog, fatigue, muscle fatigue / weakness, among many others.

Symptoms of ammonia toxicity (which can affect people with low BH4 levels) can range from mental confusion, space, language problems, poor concentration, dark circles, learning and memory problems, as well as food intolerances (particularly protein ). In some rare cases, it may also be necessary for those with liver or kidney problems.

It can also cause other mental / physical symptoms, such as anxiety and depression. When there are lower levels of BH4, ammonia detoxification will be prioritized over other essential functions, such as neurotransmitter production. Neurotransmitters can affect many functions in the body, such as mood, appetite, memory, and general mental function.

To compensate for the reduced amount of protein in the diet, it may be necessary to supplement with amino acids to compensate for the lack of amino acids from lower amounts of protein. There are certain foods that contain higher amounts of ammonia than others, a list of them can be found here: http://wholefoodcatalog.info/nutrient/ammonia/foods/high/

As you can see from the list, it would be beneficial to follow a paleo template diet with a reduced amount of protein. To further compensate for the reduced amounts of protein, it would also help increase the amount of carbohydrates and fats.

Proper supplementation can also help, but it should be done with a healthcare professional well-trained or well versed in methylation and complex health issues. Finding help for people with mthfr, detoxification can be difficult as many are unaware or know very little about treating these problems.

Addressing adrenal, thyroid, and gastrointestinal health is also important when dealing with such complex health issues. I found this note particularly helpful, especially for explaining ammonia issues and treatment goals when it comes to certain SNPS: https://www.facebook.com/notes/insight-naturopathy/mthfr-a1298c-polymorphism/385764944792649